TDAH nas Epilepsias: Prevalência e Fatores de Risco
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O Transtorno de Déficit de Atenção e Hiperatividade (TDAH) representa uma das comorbidades mais prevalentes da epilepsia, mas a associação entre ambas as condições é pouco compreendida. Esta revisão sistemática da literatura foi realizada em base de dados eletrônica (Medline/Pubmed), no recorte 2011-2016, com o objetivo de investigar os fatores associados à comorbidade. Aplicados os critérios de elegibilidade, foram selecionados 15 artigos. A prevalência de TDAH na epilepsia variou amplamente de 5,3% a 64,9%. Apesar de o TDAH estar presente nas epilepsias focais e generalizadas, alguns tipos ou síndromes epilépticas, como a epilepsia rolândica e a epilepsia frontal, foram fortemente associados aos sintomas de TDAH, especialmente naqueles indivíduos com epilepsia recém-diagnosticada, com crises pouco controladas e com eletroencefalograma anormal.
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Referências
Alfstad, K. Å., Torgersen, H., Van Roy, B., Hessen, E., Hansen, B. H., Henning, O., Clench-Aas, J., Mowinckel, P., Gjerstad, L., & Lossius, M. I. (2016). Psychiatric co morbidity in children and youth with epilepsy: An association with executive dysfunction? Epilepsy & Behavior, 56, 88-94. DOI: 10.1016/j.yebeh.2016.01.007.
American Psychiatric Association. (2014). Manual diagnóstico e estatístico de transtornos mentais (5º ed) (M. I. C. Nascimento et al., Trad.). Porto Alegre: Artmed.
Bedoin, N., Ciumas, C., Lopez, C., Redsand, G., Herbillon, V., Laurent, A. & Ryvlin, P. (2012). Disengagement and inhibition of visual–spatial attention are differently impaired in children with rolandic epilepsy and Panayiotopoulos syndrome. Epilepsy & Behavior, 25(1), 81-91. DOI: 10.1016/j.yebeh.2012.05.025.
Berl, M. M., Terwilliger, V., Scheller, A., Sepeta, L., Walkowiak, J., & Gaillard, W. D. (2015). Speed and complexity characterize attention problems in children with localization-related epilepsy. Epilepsia, 56(6), 833-840. DOI: 10.1111/epi.12985.
Brabcova, D., Zarubova, J., Kohout, J., Jošt, J. & Kršek, P. (2015). Effect of learning disabilities on academic self-concept in children with epilepsy and on their qua lity of life. Research in Developmental Disabilities, 45, 120-128. DOI: 10.1016/j. ridd.2015.07.018.
Camfield, P. & Camfield, C. (2015). Incidence, prevalence and aetiology of seizures and epilepsy in children. Epileptic Disorders, 17(2), 117-123. DOI: 10.1684/epd.2015.0736.
Chaudhary, U. J., Centeno, M., Carmichael, D. W., Vollmar, C., Rodionov, R., Bonelli, S., Stretton, J., Pressler, R., Eriksson, S. H., Sisodiya, S., Friston, K., Duncan, J. S., Lemieux, L., & Koepp, M. (2013). Imaging the interaction: epileptic discharges, working memory, and behavior. Human Brain Mapping, 34(11), 2910-2917. DOI: 10.1002/hbm.22115.
Chidi, I. R., Chidi, N. A., Ebele, A. A., & Chinyelu, O. N. (2014). Co-Morbidity of at tention deficit Hyperactivity Disorder (ADHD) and epilepsy in children seen In University of Nigeria Teaching Hospital Enugu: Prevalence, Clinical and social correlates. The Nigerian Postgraduate Medical Journal, 21(4), 273-278.
Costa, C. R. C. M. D., Oliveira, G. D. M., Gomes, M. D. M., & Maia Filho, H. D. S. (2015). Clinical and neuropsychological assessment of attention and ADHD comorbidity in a sample of children and adolescents with idiopathic epilepsy. Arquivos de Neuro-psiquiatria, 73(2), 96-103. DOI: 10.1590/0004-282X20140219.
Dafoulis, V. & Kalyva, E. (2012). Factors associated with behavioral problems in chil dren with idiopathic epilepsy. Epilepsy Research, 100(1), 104-112. DOI: 10.1016/j.eplepsyres.2012.01.014.
Dinkelacker, V., Xin, X., Baulac, M., Samson, S. & Dupont, S. (2016). Interictal epileptic discharge correlates with global and frontal cognitive dysfunction in temporal lobe epilepsy. Epilepsy & Behavior, 62, 197-203. DOI: 10.1016/j.yebeh.2016.07.009
Duran, M. H., Guimarães, C. A., Montenegro, M. A., Neri, M. L., & Guerreiro, M. M. (2014). ADHD in idiopathic epilepsy. Arquivos de Neuro-psiquiatria, 72(1), 12-16. DOI: 10.1590/0004-282X20130193.
Faure, J. B., Marques-Carneiro, J. E., Akimana, G., Cosquer, B., Ferrandon, A., Her beaux, K., ... & Cassel, J. C. (2014). Attention and executive functions in a rat model of chronic epilepsy. Epilepsia, 55(5), 644-653. DOI: 10.1111/epi.12549
Ferrie, C. D., Madigan, C., Tilling, K., Maisey, M. N., Marsden, P. K. & Robinson, R. O. (1997). Adaptive and maladaptive behaviour in children with epileptic encephalopathies: correlation with cerebral glucose metabolism. Developmental Medicine & Child Neurology, 39(9), 588-595. DOI: 10.1111/j.1469-8749.1997.tb07494.x
Filippini, M., Ardu, E., Stefanelli, S., Boni, A., Gobbi, G., & Benso, F. (2016). Neurop sychological profile in new-onset benign epilepsy with centrotemporal spikes (BECTS): Focusing on executive functions. Epilepsy & Behavior, 54, 71-79. DOI: 10.1016/j.yebeh.2015.11.010
Fisher, R. S., Boas, W. V. E., Blume, W., Elger, C., Genton, P., Lee, P., & Engel, J. (2005). Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 46(4), 470-472. DOI: 10.1111/j.0013-9580.2005.66104.x
Fonseca, L. C., Tedrus, G. M., Tonelotto, J. M. D. F., Antunes, T. D. A., & Chiodi, M. G. (2004). School performance in children with benign childhood epilepsy with centrotemporal spikes. Arquivos de Neuro-psiquiatria, 62(2B), 459-462. DOI: S0004-282X2004000300015
Gencpinar, P., Kalay, Z., Turgut, S., Bozkurt, Ö., Duman, Ö., Ozel, D., & Haspolat, S. (2016). Evaluation of Executive Functions in Patients With Childhood Absence Epilepsy. Journal of Child Neurology, 31(7), 824-30. DOI: 10.1177/0883073815623632
Gonzalez-Heydrich, J., Hamoda, H. M., Luna, L., Rao, S., McClendon, J., Rotella, P., Waber, D., Boyer, K., Faraone, S. V., Whitney, J., Guild, D., & Biederman, J. (2012). Elevated rates of ADHD in mothers of children with comorbid ADHD and epi lepsy. Neuropsychiatry, 2(5), 385-391. DOI: 10.2217/npy.12.53
Hamoda, H. M., Guild, D. J., Gumlak, S., Travers, B. H., & Gonzalez-Heydrich, J. (2009). Association between attention-deficit/hyperactivity disorder and epilepsy in pediatric populations. Expert Review of Neurotherapeutics, 9(12), 1747-1754. DOI: 10.1586/ern.09.128.
Kang, S. H., Yum, M. S., Kim, E. H., Kim, H. W., & Ko, T. S. (2015). Cognitive function in childhood epilepsy: importance of attention deficit hyperactivity disorder. Journal of Clinical Neurology, 11(1), 20-25. DOI: 10.3988/jcn.2015.11.1.20.
Kaufmann, R., Goldberg-Stern, H., & Shuper, A. (2009). Attention-deficit disorders and epilepsy in childhood: incidence, causative relations and treatment possibilities. Journal of Child Neurology, 24(6), 727-733. DOI: 10.1177/0883073808330165.
Kim, E. H., Yum, M. S., Kim, H. W., & Ko, T. S. (2014). Attention-deficit/hyperactivi ty disorder and attention impairment in children with benign childhood epilepsy with centrotemporal spikes. Epilepsy & Behavior, 37, 54-58. DOI: 10.1016/j.yebeh.2014.05.030.
Kim, G. H., Kim, J. Y., Byeon, J. H., Eun, B. L., Rhie, Y. J., Seo, W. H., & Eun, S. H. (2012). Attention deficit hyperactivity disorder in epileptic children. Journal of Korean Medical Science, 27(10), 1229-1232. DOI: 10.3346/jkms.2012.27.10.1229
Kwong, K. L., Lam, D., Tsui, S., Ngan, M., Tsang, B. & Lam, S. M. (2016). Attention Deficit Hyperactivity Disorder in Adolescents With Epilepsy. Pediatric Neurology, 57, 56-63. DOI: 10.1016/j.pediatrneurol.2015.12.022
Lo-Castro, A. & Curatolo, P. (2014). Epilepsy associated with autism and attention deficit hyperactivity disorder: Is there a genetic link? Brain and Development, 36(3), 185-193. DOI: 10.1016/j.braindev.2013.04.013
Pineda, E., Jentsch, J. D., Shin, D., Griesbach, G., Sankar, R. & Mazarati, A. (2014). Behavioral impairments in rats with chronic epilepsy suggest comorbidity betwe en epilepsy and attention deficit/hyperactivity disorder. Epilepsy & Behavior, 31, 267-275. DOI: 10.1016/j.yebeh.2013.10.004.
Rai, V. K., Shukla, G., Afsar, M., Poornima, S., Pandey, R. M., Rai, N., Goyal, V., Sriv astava, A., Vibha, D., & Behari, M. (2015). Memory, executive function and lan guage function are similarly impaired in both temporal and extra temporal refractory epilepsy – a prospective study. Epilepsy Research, 109, 72-80. DOI: 10.1016/j.eplepsyres.2014.09.031
Ramos, F. O., Carreiro, L. R. R., Scorza, F. A. & Cysneiros, R. M. (2016). Impaired ex ecutive functions in experimental model of temporal lobe epilepsy. Arquivos de Neuro-psiquiatria, 74(6), 470-477. DOI: 10.1590/0004-282X20160070.
Tanabe, T., Kashiwagi, M., Shimakawa, S., Tamai, H. & Wakamiya, E. (2014). Outpa tient screening of Japanese children with epilepsy for attention-deficit/hyperac tivity disorder (AD/HD). Brain and Development, 36(4), 301-305. DOI: 10.1016/j.braindev.2013.05.005
Thurman, D. J., Beghi, E., Begley, C. E., Berg, A. T., Buchhalter, J. R., Ding, D., Hes dorffer, D. C., Hauser, W. A., Kasis, L., Kobau, R., Kroner, B., Labiner, D., Liow, K., Logroscino, G., Medina, M.T., Newton, C. R., Parko, K., Paschal, A., Preux, P. M.., Sander, J. W., Selassie, A., Theodore, W., Tomson, T., Wiebe, S., & ILAE Commission on Epidemiology (2011). Standards for epidemiologic studies and surveillan ce of epilepsy. Epilepsia, 52(s7), 2-26. DOI: 10.1111/j.1528-1167.2011.03121.x
Tovia, E., Goldberg-Stern, H., Ben Zeev, B., Heyman, E., Watemberg, N., Fattal-Va levski, A., & Kramer, U. (2011). The prevalence of atypical presentations and co morbidities of benign childhood epilepsy with centrotemporal spikes. Epilepsia, 52(8), 1483-1488. DOI: 10.1111/j.1528-1167.2011.03136.x.
Williams, A. E., Giust, J. M., Kronenberger, W. G., & Dunn, D. W. (2016). Epilepsy and attention-deficit hyperactivity disorder: links, risks, and challenges. Neuropsychiatric Disease and Treatment, 12, 287. DOI: 10.2147/NDT.S81549
Zhang, D. Q., Li, F. H., Zhu, X. B. & Sun, R. P. (2014). Clinical observations on atten tion-deficit hyperactivity disorder (ADHD) in children with frontal lobe epilepsy. Journal of Child Neurology, 29(1), 54-57. DOI: 10.1177/0883073812470004.